Tornado Technology
Enabling RNA therapeutics by overcoming RNA instability
At Chimerna, our mission is to develop first-in-class RNA solutions for the next generation of therapeutics. Our platform technology for generating circular RNA overcomes the major limitations of RNA therapeutics – stability and abundance. We are continually evolving this technology with exciting developments in the pipeline. Chimerna scientists are leveraging this technology to treat a wide range of diseases including Alzheimer’s and Parkinson’s Diseases, ALS (Lou Gehrig’s Disease), and Non-alcoholic steatohepatitis (NASH).
Our team
Brian Pickering, Ph.D., Chief Executive Officer
Brian has been working in drug discovery since 2005 when he led a team to develop vaccines and therapeutics across a number of different diseases. His research has been the basis of multiple biotech and pharmaceutical start-ups. Brian has authored dozens of research papers and patents covering both basic and translational research. He received his B.S. from Texas A&M University, a Ph.D. in Medical Biodefense from George Mason University, a Ph.D. in Biomedical Sciences from The University of Texas MD Anderson Cancer Center. He completed his post-doctoral studies at the Weill Cornell Medical College.
Jacob Litke, Ph.D., Chief Scientific Officer, President
Jacob has over a decade of research experience focused on nucleic acids and biotechnology development. He is an expert in aptamer development, fluorescence imaging, and biophysical methods. Jacob was responsible for conceiving and ultimately developing Chimerna's Tornado technology. He also has years of experience in overseeing day-to-day operations of a large research lab, fulfilling leadership and organizational roles. Jacob received his B.A. and M.A. in Molecular Biology & Biochemistry from Wesleyan University and his Ph.D. from the Tri-Institutional PhD Program in Chemical Biology at Weill Cornell Medical College.
Scientific advisor
Samie Jaffrey, MD, Ph.D
Greenburg-Starr Professor
Weill Cornell Medicine
Dr. Jaffrey received an M.D. and Ph.D. in 1999 from Johns Hopkins School of Medicine where he also conducted postdoctoral research.
Dr. Jaffrey’s work has fundamentally advanced our understanding of
RNA biology and gene regulation. His lab originally developed the
Tornado technology. His research has been a driving force for biotechnology and therapeutic applications of RNA.
Dr. Jaffrey’s is an elected member of the American Society for Clinical Investigation, and the recipient of the 2017 John J. Abel Award in Pharmacology, Klingenstein Neuroscience Award, Irma T. Hirschl Scholar Award, the McKnight Foundation Technology Development Award, NIH EUREKA Award, the NIH Director’s Transformative R01 Award, the 2013 Blavatnik Award for Young Scientists, and the 2014 American Society for Biochemistry and Molecular Biology Young Investigator Award.